Listening with an Ageing Brain – a Cognitive Challenge
Hearing impairment has been recently identified as a major modifiable risk factor for cognitive decline in later life and has been becoming of increasing scientific interest. Sensory and cognitive decline are connected by complex bottom-up and top-down processes, a sharp distinction between sensation, perception, and cognition is
Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood-brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways. However, nasal physiology
Depression in Major Neurodegenerative Diseases and Strokes: A Critical Review of Similarities and Differences among Neurological Disorders
Depression and anxiety are highly prevalent in most neurological disorders and can have a major impact on the patient’s disability and quality of life. The early detection and treatment of depression simultaneously with the neurological disorder is key
Hematopoietic Stem Cell Transplantation for the Treatment of Autoimmune Neurological Diseases: An Update
Over the last two decades, hematopoietic stem cell transplantation (HSCT) has been explored as a potential therapeutic strategy for autoimmune diseases refractory to conventional treatments, including neurological disorders. Although both autologous (AHSCT) and allogeneic HSCT (allo-HSCT) were investigated, AHSCT was
A Case of Hypernatremia with Dementia
A 56-year-old female with a history of hypertension, coronary artery disease, chronic kidney disease, chronic hypernatremia, bipolar disorder with psychotic features, bilateral hand tremors admitted for increased aggressiveness and agitation. The patient was baseline aggressive in nature, but it had worsened in severity in the
Inflammatory brain lesions preceding primary central nervous system lymphoma: a case report and genetic analysis
A 66-year-old man presented with left limb weakness and ataxia His past medical history included thyroidectomy and gastric ulcer perforation surgery. Cranial MRI disclosed the right frontal lobular surgical remnant and a