Effects of Bipolar Disorder and Valproate Treatment on Striatal Dopamine Transporters
The dopamine transporter regulates the reuptake of extracellular dopamine into presynaptic neurons and its dysfunction could lead to mood and behavior abnormalities as observed in bipolar disorder. Previously conducted
Mania and Traumatic Brain Injury: Is there any association?
Mania is defined as an uncommon but debilitating psychiatric occurrence following traumatic brain injury. Traumatic brain injury is a leading cause of mortality and morbidity. 74% of people develop mania within 1 year following traumatic brain injury.
The illness trajectory varied from a single manic episode to recurrent mood episodes. In some patients, rapid cycling is also reported. Rapid cycling refers to the presence of at least 4 mood outbreaks in the last 12 months that meet the measures for hypomanic, manic, or major depressive disorder.