Misfolded GBA/β-glucocerebrosidase impairs ER-quality control by chaperone-mediated autophagy in Parkinson disease.
![](https://sciaxis.org/wp-content/uploads/2023/05/brain-is-shown-table-dark-room.jpg)
![](https://sciaxis.org/wp-content/uploads/2023/05/brain-is-shown-table-dark-room.jpg)
Inhibition of chaperone-mediated autophagy (CMA), a selective type of lysosomal degradation for intracellular proteins, may contribute to pathogenesis in neurodegenerative diseases including Parkinson disease (PD). Pathogenic variants