Lack of association between PLA2G6 genetic variation and Parkinson’s disease: a systematic review
INTRODUCTION: The phospholipase A2 Group 6 (PLA2G6, also known as PLA2, PARK14, and iPLA2) gene encodes a group via calcium-independent phospholipase A2. Genetic polymorphism of PLA2G6 has been indicated to be involved in conferring susceptibility for Parkinson’s disease (PD), whereas conclusive results have not been obtained. OBJECTIVE: To conduct a systematic review to determine if PLA2G6 genetic variation confers greater susceptibility […]
Effect of deep brain stimulation on female Parkinsonian patients with lower urinary tract symptoms
Lower urinary tract symptoms (LUTS) are common in Parkinson’s disease cases as 60% of these patients have bladder storage/ emptying disturbances. The most common symptoms seen in Parkinson’s disease patients are urgency, frequency, and urgency UI. Urodynamic studies have shown that a high proportion of Parkinson’s patients have overactive bladder(OAB). The pathophysiology of OAB symptoms […]
Sleepwalking and REM sleep Behaviour Disorder Linked to Parkinson’s Disease in Men
Introduction Even though Parkinson’s disease is a movement disorder, several non-motor features such as REM and sleep behaviour disorder have been frequently observed. Previous studies have proposed sleepwalking to be highly prevalent in Parkinson’s disease patients. Objective To assess whether probable sleepwalking, either alone or in conjunction with probable REM Sleep Behaviour Disorder is associated […]
Robotic Method Marks the End of Uncertainty in Parkinson’s Hallucinations in Disease
A study comprising of 26 patients with Parkinson’s disease (PD) utilized a robotic method to initiate “presence hallucinations” and found that altered sensorimotor processing in the frontotemporal network could be the cause behind hallucinations that are experienced by the PD patients. These findings led to the identification of the neural network that is responsible for […]