Epigenetics of Thymic Epithelial Tumors
The thymus is the primary lymphoid organ designated to the adaptive humoral immunity construction. It guarantees immune self-tolerance by operating the positive and negative selection of the T cells during their development and maturation, avoiding autoimmune
Neuromuscular Disorders Associated With COVID-19
The coronavirus disease 2019 (COVID-19) pandemic has had a huge impact on practically every aspect of daily life, and those with neuromuscular disorders have certainly not been spared. Early in the pandemic, the heterogeneity of disease was vast. The majority
Anesthesia for Patients with Myasthenia Gravis
Neuromuscular (NM) diseases are a common cause of morbidity and mortality. Myasthenia gravis (MG) is characterized by skeletal muscle weakness and fatigability. In essence, MG is an autoimmune disease that results from the destruction of post-synaptic nicotinic acetylcholine (ACh)
Randomized Double-Blind Placebo-Controlled Trial of the Corticosteroid-Sparing Effects of Immunoglobulin in Myasthenia Gravis
Introduction Myasthenia gravis (MG) is an autoimmune disease characterized by dysfunction at the neuromuscular junction. Treatment frequently includes corticosteroids (CSs) and IV immunoglobulin (IVIG). Treatment of severe MG or exacerbations frequently includes plasma exchange or IV immunoglobulin (IVIG). Plasma exchange was shown to improve muscle strength in patients with MG. Treatment with IVIG was found to produce […]
Inflammation and autoimmune myasthenia gravis
Myasthenia gravis (MG) is a neuromuscular autoimmune disorder characterized by chronic but intermittent fatigue of the eye- and general body muscles. Muscle weakness is caused primarily by the binding of an autoantibody to the acetylcholine receptors, resulting in blockage of normal neuromuscular signal transmission. Inflammation has long been regarded as an important contributing factor for […]
Prevalence of depression and anxiety among myasthenia gravis (MG) patients: A systematic review and meta-analysis
Introduction In MG, the transmission of nerve impulses to the muscles is disrupted. When there is no nerve–muscle connection, muscles are disrupted and cause neuromuscular disorders in these patients. Myasthenia gravis (MG) people experience adverse psychiatric outcomes, which may impact on their life and disturb their daily activity. Depression and anxiety are identified as significant […]