Preventive Approaches for Post-Stroke Depression: Where Do We Stand? A Systematic Review
Background Post-stroke depression (PSD) occurs in one-third of stroke survivors, leading to a substantial decrease in quality of life as well as delayed functional and neurological recovery. Early detection of patients at risk and initiation of tailored preventive measures may reduce the medical and socioeconomic burden associated with PSD. Objective To review the current evidence […]
Risk factors for depression in tuberculosis patients
Mental illness is an important global health concern, with depression affecting nearly 322 million people worldwide. Studies on the comorbidity of TB and depression reveal a significant correlation between depression and poor adherence to TB treatment, as well as higher rates of treatment failure, development of antimicrobial resistance, and higher mortality rates TB infection causes […]
Efficacy of Omega-3 polyunsaturated fatty acid in Depression
Omega-3 PUFAs are the essential fatty acids used to produce Eicosapentaenoic acid (EPA) from EPA, they then synthesize DHA. EPA can decrease the production of arachidonic acid by inhibiting delta-5-desaturase activity. In the cyclooxygenase enzyme system, EPA may compete with arachidonic acid for phospholipase A2 (PLA2) and help block the process of proinflammatory eicosanoid synthesis from […]
DEPRESSION IN PATIENTS WITH KNEE OSTEOARTHRITIS
Osteoarthritis (OA) is a prevalent joint disease, characterized by whole joint structural changes, and is considered a serious disease. Studies indicate that chronic pain results in a series of changes, specifically fatigue, and disability which results in depression. Individuals who experienced chronic pain and physical activity limitation are at increased risk of depression. Pain incites […]
Blood Biomarkers in Mood Disorders
Blood biomarkers are set to improve diagnosis of highly co-morbid and disabling mood disorders such as depression and bipolar disorder. A study was conducted with the view of providing targeted therapeutics and for enabling precision medicine for mood disorders. It consisted of three independent cohorts for discovery, validation and testing, respectively. The rating scales included […]
Gut Dysbiosis Markers in Severe Mental Illness
Introduction Gut dysbiosis has been correlated with innumerable poor health outcomes including severe mental illnesses such as bipolar disorder, depression amongst others. It is believed to trigger a chronic low-grade pro-inflammatory status by increasing the gut-barrier permeability. Based on previous studies, elevated pro-inflammatory cytokine levels have been observed in patients suffering from schizophrenia, depression and […]