Deficiency of vitamin D leads to Alzheimer’s and dementia
Low vitamin D concentrations are associated with prevalent Alzheimer’s dementia and cognitive impairment. 1,25-Dihydroxy vitamin D3 receptor and 1α-hydroxylase, the enzyme responsible for synthesizing the bioactive form of vitamin D, are found throughout the human brain. Alzheimer’s is caused by the abnormal build-up of amyloid plaques. In vitro, vitamin D increases the phagocytic clearance […]
Active Brain to Delay Alzheimer’s Onset
A longitudinal cohort study claims that high level of cognitive activity in older age may delay the onset of alzheimer’s disease by nearly 5 years. 1,903 old participants were enrolled for annual cognitive clinical evaluations and neuropathologic examination after death. Cognitive activity at baseline and time of diagnosis along with postmortem markers of alzheimer’s and […]
Mortality Rates in Alzheimer’s and Other Dementias
Other types of dementias could be more concerning than alzheimer’s disease due to high mortality rates, says a new study. A systematic review and meta-analysis was performed including 78 studies to compare the difference in mortality rates between those without dementia and with various types of dementia. The study encompassed 63125 individuals with dementia and […]
Sleep Problems and Dementia
A study reports that shorter the sleep one takes during the midlife higher is the risk of late-onset dementia. The study included 7959 participants of the Whitehall II study to examine the association between sleep duration and incidence of dementia using over 25 years. 521 participants developed dementia mostly after the age of 70 years. […]
Incidence of Non-Motor Seizures in Parkinson’s Disease
Case Presentation An 82-year-old woman was having Incidence of Non-Motor Seizures in Parkinson’s disease with episodes of protracted confusion and unresponsiveness without recollection of her actions. Medical History At the age of 76, Clinical Exam An electroencephalogram (EEG) was obtained and the video displayed left temporal sharp wave and focal left temporal slowing. Fig 1: […]