A Case of Hypernatremia with Dementia
A 56-year-old female with a history of hypertension, coronary artery disease, chronic kidney disease, chronic hypernatremia, bipolar disorder with psychotic features, bilateral hand tremors admitted for increased aggressiveness and agitation. The patient was baseline aggressive in nature, but it had worsened in severity in the
Adjunctive lumateperone (ITI-007) in the treatment of bipolar depression: Results from a randomized placebo-controlled clinical trial
Bipolar disorder is a chronic disorder characterized by a significant disease burden. While many agents effectively treat symptoms of mania, treatments for depressive episodes associated with bipolar disorder are limited. Lumateperone, a mechanistically
Is Adjunctive Interpersonal and Social Rhythm Therapy Beneficial for Patients with Bipolar Disorder?
Interpersonal and social rhythm therapy in the treatment of bipolar disorder can assist patients in reducing the stressors leading to acute episodes. The ideal treatment for bipolar disorder includes treatment of an episode
Effects of Bipolar Disorder and Valproate Treatment on Striatal Dopamine Transporters
The dopamine transporter regulates the reuptake of extracellular dopamine into presynaptic neurons and its dysfunction could lead to mood and behavior abnormalities as observed in bipolar disorder. Previously conducted
Long-Term Management of Bipolar Disorder Using Paliperidone Palmitate
Bipolar disorder patients demonstrate a high rate of medication non-adherence which ranges anywhere between 20% to 60%. Long acting injectable (LAI) drugs are considered to possess the potential to manage this non-adherence
Astrocyte-Mediated Inflammation in Bipolar Disorder
Bipolar disorder was found to have a unique inflammation pathway involving astrocytes with higher inflammatory cytokine IL-6. The study involved an in vitro model evaluating inflammation-related phenotypes of astrocytes