Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction
Chronic inflammation in the central nervous system (CNS) is a hallmark of neurodegenerative disorders such as Alzheimer’s disease. The etiology of neurodegeneration is diverse, and evidence indicates that extrinsic variables such as lifestyle and chemical exposures are connected to the development of these disorders. Neurotoxic metals have been linked to AD due to their potential to increase beta-amyloid (Aβ) peptide levels and phosphorylation
VARICELLA AND HERPES VIRUSES MAY INTERACT TO TRIGGER ALZHEIMER’S
Researchers have shown that varicella-zoster virus (VZV), which commonly causes chickenpox and shingles, may activate herpes simplex (HSV), another common virus, to set the early stages of Alzheimer’s disease. Normally HSV-1- one of the main variants of the herpes simplex virus lies dormant within the neurons of the brain. However, when it is activated it […]
ROLE OF CALCIUM HOMEOSTASIS IN ALZHEIMER’S DISEASE
Alzheimer’s disease (AD) is a neurodegenerative disease associated with senile plaques (SP) and neurofibrillary tangles (NFTs) in the brain. Abnormal accumulation of a specific protein, β-amyloid (Aβ), in brain neurons plays a central role in the pathogenesis of this neurodegenerative disease. Changes in intracellular calcium signalling are related to Alzheimer’s disease. Studies have demonstrated that […]
Deficiency of vitamin D leads to Alzheimer’s and dementia
Low vitamin D concentrations are associated with prevalent Alzheimer’s dementia and cognitive impairment. 1,25-Dihydroxy vitamin D3 receptor and 1α-hydroxylase, the enzyme responsible for synthesizing the bioactive form of vitamin D, are found throughout the human brain. Alzheimer’s is caused by the abnormal build-up of amyloid plaques. In vitro, vitamin D increases the phagocytic clearance […]