Listening with an Ageing Brain – a Cognitive Challenge
Hearing impairment has been recently identified as a major modifiable risk factor for cognitive decline in later life and has been becoming of increasing scientific interest. Sensory and cognitive decline are connected by complex bottom-up and top-down processes, a sharp distinction between sensation, perception, and cognition is
Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood-brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways. However, nasal physiology
Depression in Major Neurodegenerative Diseases and Strokes: A Critical Review of Similarities and Differences among Neurological Disorders
Depression and anxiety are highly prevalent in most neurological disorders and can have a major impact on the patient’s disability and quality of life. The early detection and treatment of depression simultaneously with the neurological disorder is key
Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease
47-year-old woman with Down syndrome presented with the complaints of fear, anxiety, confusion and memory loss.Because of her change in behavior, fear, and anxiety, she became largely housebound and struggled with fatigue, took extended naps once or twice daily, and could no longer safely be left alone for extended periods. Her primary
Atypical Presentation of Carbon Monoxide Poisoning with Aphasia
A 49-year-old male presented to the emergency department (ED) via EMS with a chief complaint of altered mental status. Per emergency medical services (EMS), the patient was found confused in his truck with a generator running
Sickle cell anemia (hemoglobin SS) status post haploidentical bone marrow transplant
A 17-year-old female with sickle cell anemia (hemoglobin SS) status post haploidentical bone marrow transplant from her biological mother 48 days prior and on tacrolimus for GVHD prophylaxis presented with acute onset expressive