Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces severe neural injuries, and is one of the leading causes of death and disability worldwide. Thus, it is of great necessity to further detailly elucidate the mechanisms of ischemic stroke and find out new therapies against the disease. In recent
A Spectrum of Rare Symptoms
A 23-year-old woman presented with the psychosis, increased appetite along with obsessive symptoms and poor hygiene. She was non-responsive to therapy for obsessive compulsive disorder. Her MRI showed diffuse, bilateral frontal temporal atrophy prominently in subarachnoid spaces, sylvian fissure and ventricles. Her Mini Mental Status Examination (MMSE) score was 13/30 and her Frontal Assessment Battery […]
A Spectrum of COVID-19 Symptoms or Alzheimer’s?
A 67-year-old woman presented with the complaints of memory loss, difficulties in concentration especially during reading and cognitive fatigue after recent recovery from COVID-19 infection. The patient had a history of type 2 diabetes mellitus being managed with metformin. Her laboratory evaluation was normal except mild elevation of C-reactive protein. Her neuropsychological assessment revealed a […]
Advanced Alzheimer’s Disease in an Elderly
An 80-year-old man with Alzheimer’s disease presented with a 4-year decline in episodic memory. Over years, the patient had gradual decline in memory, developed hesitant speech and impaired organizational skills. His family stated that he could not recognize his family members and common objects over past 6 months. His current therapy was donepezil, rivastigmine and […]
Tumefactive Demyelination in MS patient
A 32-year-old man with tumefactive multiple sclerosis presented with an early onset of escalating gait unsteadiness, lower limb weakness, and four-day-long numbness. There was no preceding fever or associated trauma, neck pain or back pain. In the past, there were episodes of imbalance, dizziness, urinary urgency and incontinence. The neurological examination of right arms and […]
A Rare Presentation of Multiple Sclerosis
A 12-year-old girl with multiple sclerosis was presented with complaints of double vision primarily associated with straight and right gaze. She had an error of refraction, her slit lamp ophthalmic examination and fundus examination were normal. The right eye’s motion was restricted on extraocular muscle evaluation and no change in vision was found. Nodular foci […]