A 68-year-old man presented with swelling on the right thigh. Magnetic resonance imaging revealed a contrast-enhanced tumor. An open biopsy was performed, and the tumor was diagnosed as leiomyosarcoma. Subsequently, the patient underwent extensive tumor resection of the right thigh leiomyosarcoma. Microscopically, a dense proliferation of tumor cells comprising a spindle and epithelioid cells with isomorphic nuclei was observed. As pathological examination indicated no tumor cells at the resection margin, the patient did not receive additional therapy. However, one year after the surgery, computed tomography indicated multiple lung metastases.
Results
a) Adriamycin
Adriamycin is widely used for the combined chemotherapy of solid tumors. Adriamycin is an antibiotic anthracycline agent that exhibits a broad spectrum of antitumoral activity. Adriamycin inhibits the signaling pathway of TGF-β1, whose upregulation has been associated with the development of lung metastases.
