A 33-year-old male with schizoaffective disorder – bipolar type, generalized anxiety disorder, stimulant use disorder (methamphetamine type), phencyclidine use disorder, and cannabis use disorder. The patient’s illness at baseline includes residual auditory hallucinations but no suicidal or homicidal ideations. Two months before admission, the patient’s outpatient medication regimen consisted of valproic acid 1000 mg daily, buspirone 15 mg three times a day, trazodone 50 mg daily, gabapentin 900 mg daily, quetiapine 300 mg daily, and paliperidone palmitate 156 mg intramuscular injections every 4 weeks. The patient exhibited traits of increased aggression, odd behaviors, and paranoia. The patient’s outpatient team reported that the patient frequently nasally ingested his buspirone and had a history of difficulty with medication adherence.
Results
b) Administrations of buspirone
Buspirone is a generally safe anxiolytic azathioprine drug, it appears to have a rare adverse reaction of exacerbating psychosis in some patients. This may be associated with the intranasal administration of buspirone, resulting in increased bioavailability, which is more commonly seen in patients with stimulant use disorder and incarceration history.
