Neuropsychiatric disorders have both neurological and psychiatric indications. The increasing burden of the disease on the population makes it essential to adopt measures to reduce its prevalence.
The Klotho is a single-pass transmembrane protein that decreases with age and is associated with various pathological diseases like cardiac problems, reduced bone mineral density, and cognitive impairment.
The Klotho levels were decreased in various neuropsychiatric disorders except for bipolar disorder. A suppressed Klotho level caused oxidative stress and incited proinflammatory conditions significantly contributing to the neuropsychiatric disorder pathophysiology. Klotho protein is considered a biomarker in various neuropsychiatric disorders.
