Diabetes and Alzheimer’s disease (AD) are associated with specific changes in the composition of the intestinal flora. Studies have shown that the supplementation with pasteurized Akkermansiamuciniphila has therapeutic and preventive effects on diabetes.It is found that pasteurized Akkermansiamuciniphila can significantly improve the blood glucose, body mass index, and diabetes indexes of zebrafish with diabetes mellitus complicated with Alzheimer’s disease and also alleviate the related indexes of Alzheimer’s disease.
The memory, anxiety, aggression, and social preference behavior of zebrafish with combined type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (TA zebrafish) were significantly improved after pasteurized Akkermansiamuciniphila treatment. Moreover, preventive effect of pasteurized Akkermansiamuciniphila on diabetes mellitus complicated with alzheimer’s disease were examined. The results showed that the zebrafish in the prevention group were better in terms of biochemical index and behavior than the zebrafish in the treatment group. These findings provide new ideas for the prevention and treatment of diabetes mellitus complicated with Alzheimer’s disease
