Tumor relapse induced by extramedullary infiltrate poses the largest threat to patient survival. The central nervous system is one of the extramedullary places where cancer manifests itself most frequently. The blood-brain barrier (BBB), a special structure in the CNS, protects the brain from blood borne pathogens via its excellent barrier properties and hinders new drug development for a brain tumor.
Recent breakthroughs in nanotechnology have resulted in different nanovehicles as drug carriers to cross the BBB by various methods. Several different strategies of therapeutic delivery have been developed to transport chemotherapeutic medications across the BBB to treat a brain tumor. Due to their distinct advantages, nano-vehicle-based systems have been intensively examined to create a synthetic platform for brain medication delivery.
