Long non-coding RNAs (lncRNAs) have been reported to be involved in the pathogenesis of neurodegenerative diseases. In this systematic review, we compiled all studies on the subject to evaluate the accuracy of lncRNAs in identifying AD cases through meta-analysis.A PRISMA-compliant systematic search was conducted. All observational studies published which investigated the sensitivity and specificity of various lncRNAs in plasma samples of AD diagnosis were included. To account for the predicted heterogeneity of the study, a random-effects model was used. All the statistical analyses and visualizations were conducted using Stata 17.0 software. The pooled diagnostic odds ratio (DOR) of the five individual lncRNAs in AD diagnosis was 20. The given study suggested that lncRNAs had high accuracy in identifying AD and must be seen as a promising diagnostic biomarker of the disease.
