T-1 weighted structural magnetic resonance imaging is widely used to estimate brain morphometry (e.g., cortical thickness and subcortical volumes). Accelerated scans as fast as one minute or less are now available, but it is unclear if they are sufficient for quantitative morphometry. Regions of lower reliability and relative divergence between the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and rapid scan alternatives tended to occur in the midline region and regions with susceptibility-induced artifacts. Critically, the immediate scans generated morphometric estimates similar to the ADNI and immediate scan in regions of high atrophy.
