Efficacy of Omega-3 polyunsaturated fatty acid in Depression
Omega-3 PUFAs are the essential fatty acids used to produce Eicosapentaenoic acid (EPA) from EPA, they then synthesize DHA. EPA can decrease the production of arachidonic acid by inhibiting delta-5-desaturase activity. In the cyclooxygenase enzyme system, EPA may compete with arachidonic acid for phospholipase A2 (PLA2) and help block the process of proinflammatory eicosanoid synthesis from […]
DEPRESSION IN PATIENTS WITH KNEE OSTEOARTHRITIS
Osteoarthritis (OA) is a prevalent joint disease, characterized by whole joint structural changes, and is considered a serious disease. Studies indicate that chronic pain results in a series of changes, specifically fatigue, and disability which results in depression. Individuals who experienced chronic pain and physical activity limitation are at increased risk of depression. Pain incites […]
Cariprazine as a treatment option for depressive episodes associated with bipolar 1 disorder in adults
Depressive episodes are the most frequent episodes in bipolar disorder. Few treatments, however, have been approved by the FDA for the treatment of bipolar depression. Cariprazine, a broad-spectrum dopamine antagonist/partial agonist with dopamine D3/D2 and serotonin 5-HT1A receptor partial agonist properties, was recently approved. Partial agonism/antagonism at D3 receptors inhibits the activity of somatodendritic D3 […]
The relationship between antipsychotic-induced akathisia and suicidal behaviour: a systematic review
INTRODUCTION: Akathisia (Greek “not to sit”) is a movement disorder characterized by a subjective, inner sense of restlessness and difficulty in staying still and is often related to the initiation of or rapid escalation of antipsychotic medication.1 Akathisia is commonly accompanied by escalated levels of anxiety, agitation and dysphoric affect. OBJECTIVE: The aim of the study […]
Blood Biomarkers in Mood Disorders
Blood biomarkers are set to improve diagnosis of highly co-morbid and disabling mood disorders such as depression and bipolar disorder. A study was conducted with the view of providing targeted therapeutics and for enabling precision medicine for mood disorders. It consisted of three independent cohorts for discovery, validation and testing, respectively. The rating scales included […]
Gut Dysbiosis Markers in Severe Mental Illness
Introduction Gut dysbiosis has been correlated with innumerable poor health outcomes including severe mental illnesses such as bipolar disorder, depression amongst others. It is believed to trigger a chronic low-grade pro-inflammatory status by increasing the gut-barrier permeability. Based on previous studies, elevated pro-inflammatory cytokine levels have been observed in patients suffering from schizophrenia, depression and […]