Clozapine in Treatment-Resistant Bipolar Disorder With Suicidality
A 42-year-old female was admitted to the inpatient psychiatry unit due to a severe depressive episode in the course of BD. Before admission, she had quarrelled with her husband, and under the influence of ethanol, she had tried to commit suicide by cutting her wrist.. During hospitalization, she was treated with venlafaxine 375 mg, lamotrigine 200 mg, […]
COVID-19 treatment-induced neuropsychiatric adverse effects
COVID-19 represents a major challenge in the field of psychiatry, as both the virus and the medications used to treat it may induce neurologic and psychiatric symptoms. Antiretroviral drugs used for the treatment of COVID-19 may produce undesirable effects on the central and peripheral nervous systems. Cytochrome p450 enzymes are affected by protease inhibitors which […]
Cariprazine as a treatment option for depressive episodes associated with bipolar 1 disorder in adults
Depressive episodes are the most frequent episodes in bipolar disorder. Few treatments, however, have been approved by the FDA for the treatment of bipolar depression. Cariprazine, a broad-spectrum dopamine antagonist/partial agonist with dopamine D3/D2 and serotonin 5-HT1A receptor partial agonist properties, was recently approved. Partial agonism/antagonism at D3 receptors inhibits the activity of somatodendritic D3 […]
Patient with Bipolar Disorder Demonstrating Lithium-Associated Hypercalcemia
Case Presentation A 68-year-old woman was presented with a vicious onset of sub confusion, insomnia and visual hallucinations. Medical History Clinical Exam Her evaluation revealed: Her imaging revealed: Diagnosis The patient was diagnosed with parathyroid adenoma. Treatment Five days after admission, Follow-Up
Blood Biomarkers in Mood Disorders
Blood biomarkers are set to improve diagnosis of highly co-morbid and disabling mood disorders such as depression and bipolar disorder. A study was conducted with the view of providing targeted therapeutics and for enabling precision medicine for mood disorders. It consisted of three independent cohorts for discovery, validation and testing, respectively. The rating scales included […]
Gut Dysbiosis Markers in Severe Mental Illness
Introduction Gut dysbiosis has been correlated with innumerable poor health outcomes including severe mental illnesses such as bipolar disorder, depression amongst others. It is believed to trigger a chronic low-grade pro-inflammatory status by increasing the gut-barrier permeability. Based on previous studies, elevated pro-inflammatory cytokine levels have been observed in patients suffering from schizophrenia, depression and […]