Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood-brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways. However, nasal physiology
A Case of Hypernatremia with Dementia
A 56-year-old female with a history of hypertension, coronary artery disease, chronic kidney disease, chronic hypernatremia, bipolar disorder with psychotic features, bilateral hand tremors admitted for increased aggressiveness and agitation. The patient was baseline aggressive in nature, but it had worsened in severity in the
Inflammatory brain lesions preceding primary central nervous system lymphoma: a case report and genetic analysis
A 66-year-old man presented with left limb weakness and ataxia His past medical history included thyroidectomy and gastric ulcer perforation surgery. Cranial MRI disclosed the right frontal lobular surgical remnant and a
Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer’s disease
47-year-old woman with Down syndrome presented with the complaints of fear, anxiety, confusion and memory loss.Because of her change in behavior, fear, and anxiety, she became largely housebound and struggled with fatigue, took extended naps once or twice daily, and could no longer safely be left alone for extended periods. Her primary
Should artificial intelligence be used in conjunction with Neuroimaging in the diagnosis of Alzheimer’s disease?
Dementia, or Major Neurocognitive Disorder (MND), is a general term for any disease that causes a substantial decline in at least one cognitive domain including memory, learning, executive function, and additionally, impairs an individual’s ability to perform daily tasks. Alzheimer’s disease (AD) can be divided into three stages: early-stage (mild), middle-stage (moderate), and late-stage (severe). Each phase serves to classify the development of
Lecanemab for Patients with Early Alzheimer Disease: Bayesian Analysis of a Phase 2b Dose-Finding Randomized Clinical Trial
Bayesian clinical trial designs are increasingly common; given their promotion by the US Food and Drug Administration, the future use of the Bayesian approach will only continue to increase. Innovations are possible when using the Bayesian approach