In Alzheimer’s disease, the accumulation and aggregation of amyloid beta (Aβ) peptide into extracellular amyloid plaques is an early event that precedes neurodegeneration and functional and cognitive impairment. Genetic variants
Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical aspects of neurodegeneration. AD involves parts of the brain that control thought, language, and memory. AD is a progressive disease that begins
Bipolar disorder is a chronic disorder characterized by a significant disease burden. While many agents effectively treat symptoms of mania, treatments for depressive episodes associated with bipolar disorder are limited. Lumateperone, a mechanistically
Major depressive disorder impacts approximately 264 million people worldwide and is a leading cause of the global disability burden. In major depressive disorder (MDD), cognitive dysfunctions strongly contribute to functional
Previous studies suggested the benefit of argatroban plus alteplase (recombinant tissue-type plasminogen activator) in patients with acute ischemic stroke (AIS). However, strong evidence in trials with large sample sizes
Hereditary transthyretin (ATTR variant) amyloidosis, also called hATTR amyloidosis is a rare, rapidly progressive, debilitating, and fatal disease caused by transthyretin (TTR) gene variants. Misfolded TTR accumulates as amyloid
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