Introduction
Multiple system atrophy is characterized by progressive decay of the nervous systems, including the cerebellar, autonomic systems, pyramidal, and extrapyramidal tracts. MSA usually affects older adults in their 50s and 60s.
Case Presentation
A 48-year-old female was admitted to the hospital because of a balance disorder and walking difficulty due to dizziness.
Physical Examination
- At the time of admission, the patient’s vital signs were within normal limits.
- Chest X-ray and cardiac and abdominal sonography were normal.
- Tests for nystagmus indicated no limitation of ocular movements or abnormalities.
- The brain MRI demonstrated several abnormalities including the “hot cross bun” sign, a cruciform hypo intensity in the pons, and symmetric atrophy..
Medical History
- There was no history of dementia, sleep disturbances, or cognitive impairment.
- There was no history of genetic diseases or progressive neurodegenerative disorders in her family or relatives.
Clinical Examination
- The patient presented with complaints of cerebellar disorders like loss of balance, gait ataxia, coordination disturbance, titubation, and sloppy handwriting.
- There was no sign of resting or postural tremors, rigidity, or bradykinesia.
Treatment
- The patient has been treated with levodopa.
Clinical Outcome
- The patient progressed rapidly within 1 week.