Case Presentation
53 year old female had a diagnosis of major depressive disorder (MDD) and chronic constipation.
Medical History
- She was diagnosed with MDD in 2006 and had been hospitalized twice in her life.
- The patient had been in therapy as an inpatient for almost 3 months and treated for depression and constipation with persevering symptoms
Family History
- Depression is common in her family, with two male second-degree relatives having suffered from it, one deceased by suicide.
Clinical Exam
- Hamilton depression scale (HAMD), sum score was 21
- Beck depression inventory(BID-II) score was 50
- Gastrointestinal symptom-rating scale (GSRS), sum score of 79
- Gastrointestinal problems like constipation, stomach pain, bloating, burping
Treatment
- She was administered 30 oral frozen Fecal microbiota transplantation (FMT) capsules within 90 min under the observation of a physician.
- Each active 30-capsule-dose consisted of 8.25 g donor stool, originating from a single donor, which was a different donor for each patient
Clinical Outcome
- Symptoms of depression improved, indicated by a decreased HAMD score from 21 points to 9 points, 4 weeks post-intervention.
- BID-II score was decreased from 50 to 31, 4 weeks intervention.
- Gastrointestinal symptoms were also improved. GSRS score benefitted by 56 points after 4 weeks,
- Other symptoms like stomach pains, sickness, bloating, burping, and constipation were improved over time