Case Presentation
A 59-year-old female came to the hospital with the complaints of felt sadness, decreased interest, self-blame, panic, chest tightness, overall pain, loss of appetite, abdominal distention, and belching.
Physical Examination
- Physical assessment was unremarkable.
Medical History
- The patient had a previous history of psoriasis spanning more than 20 years.
- Allergy to painkillers and fish.
- She denied a history of hypertension, diabetes, cerebrovascular disease, and heart disease.
- No history of surgery or trauma. No history of attraction or alcohol consumption.
- Denied the history of hereditary disease, infectious disease.
Family History
- There was no personal or family history of psychiatric illness.
Clinical Examination
- Diagnosis ofdepression was confirmed.
- MMSE 14 points. MOCA 12 points. PET/MRI showed brain atrophy in the bilateral hippocampus, right amygdala, bilateral frontal, temporal, occipital, and right parietal lobes.
- DWI and SWI did not show any abnormal signals.
- The 18F-FDG image showed decreased glucose metabolism in the right parietal lobe, bilateral partial lobe, bilateral frontal lobe, bilateral parietotemporal joint region, and bilateral partial posterior cingulate gyrus.
- The 18F-AV45 PET image showed Aβ deposition was present in the cerebral cortex.
- Finally, Alzheimer’s disease was diagnosed.
Treatment
- Venlafaxine 150 mg prescribed to improve mood
- Memantine 5 mg in the morning and 10 mg at night was added.
Clinical Outcome
During a follow-up visit 2 weeks after discharge, the patient’s family reported that the patient is doing well and increased daytime sleep.