Mania is defined as an uncommon but debilitating psychiatric occurrence following traumatic brain injury. Traumatic brain injury is a leading cause of mortality and morbidity. 74% of people develop mania within 1 year following traumatic brain injury.
The illness trajectory varied from a single manic episode to recurrent mood episodes. In some patients, rapid cycling is also reported. Rapid cycling refers to the presence of at least 4 mood outbreaks in the last 12 months that meet the measures for hypomanic, manic, or major depressive disorder.
The heterogeneity of lesions, locations, and coexisting vulnerabilities makes causality difficult to specify. Second-generation antipsychotics or valproate may be assessed as first-line therapy. To control symptoms and prevent a recurrence early escalation to combined therapy is suggested.
