Dermoid Cyst Concomitant with Focal Cortical Dysplasia
A 17-year-old girl presented with drug-resistant epilepsy since the age of 13. She often experienced impaired awareness seizures which rarely proceeded to bilateral tonic-clonic seizures. EEG had left temporal focal slowing without epileptiform discharges while a week long video-EEG showed no changes but the patient complained of olfactory aura. Her MRI was consisted with dermoid […]
An Umbrella of Clinical Manifestations
A 7-year-old boy was presented with a diagnosis of attention deficit hyperactivity disorder. The patient was hyperactive and had the impression of difficulty with eye contact. He also had mild motor tics disorder and IQ of 76%. At 9 years, the mother reported that he turned speechless, especially when it came to interacting with strangers. […]
Adalimumab-Induced Primary Progressive Multiple Sclerosis
A 45-year-old woman was presented with progressive visual problems, gait impairment and urinary dysfunction. The patient had a history of Graves’ disease, Sjogren disease and cystic nodular acne for about a decade. Over the past 4 years, she had underwent adalimumab therapy with excellent clinical response. Her evaluation revealed MRI lesions typical for MS, positive […]
Heart-rate Variability and Disability Status in Multiple Sclerosis: Is There a Link?
A new study suggests the correlation of heart rate variability with disease disability in multiple sclerosis patients as autonomic dysfunction is common in such patients. The study evaluated the feasibility of heart rate variability as a measure of autonomic dysfunction using wearable sensors and its association with clinical measures of disease activity in 29 multiple […]
Ocrelizumab in Relapsing-Remitting and Progressive Multiple Sclerosis
Ocrelizumab was found to be effective and safe therapy in relapsing-remitting, primary-progressive and secondary-progressive multiple sclerosis patients. Performed on 153 patients (mean age: 41.9 years; 60% females; mean EDSS: 3.5), this study provided first real-world effectiveness and safety data and the possible predictors of treatment response. After 2 years, percentage disability worsening-free patients were 90.5%, […]
Blood Biomarkers in Mood Disorders
Blood biomarkers are set to improve diagnosis of highly co-morbid and disabling mood disorders such as depression and bipolar disorder. A study was conducted with the view of providing targeted therapeutics and for enabling precision medicine for mood disorders. It consisted of three independent cohorts for discovery, validation and testing, respectively. The rating scales included […]